ACE2, a protective monocarboxypeptidase, responsible for conversion of Ang II to Ang1-7, opposes the deleterious effects of RAS pathway but how its expression is altered with blockade of AT1R and AT2R is not yet known. Though Ang II has been known to activate the Nuclear Factor-κB (NF-κB) signalling pathway through different receptor subtype(s) in different tissues under various diseases, the subtype orchestrating this stimulation in type 2 diabetic kidney remains elusive. Abbud Gharghour was assigned as the postulator for the beatification process.Angiotensin II (Ang II) acts through Angiotensin Converting Enzyme (ACE)/Ang II type 1 receptor (AT1R) axis to promote renal failure whereas the Ang II type 2 receptor (AT2R)/Angiotensin Converting Enzyme 2 (ACE2)/Ang1-7/Mas axis constitutes the protective arm of Renin Angiotensin System (RAS). The diocesan process for her possible beatification started on October 20, 1995. Archbishop Fattal presided over the requiem, in which he referred to her as 'Santa Matilde'. She was buried alongside her husband, Georges, and was interred into the Salesian Church there. She returned to Aleppo and died on February 7, 1961, aged 56. She then traveled to the famous Grotto of Our Lady of Lourdes in Lourdes, France. In March 1960 however, while slowly returning to her regular life of active service, the cancerous malignancy returned. The treatment was initially considered a success, which allowed her to return to her home that very same year. In response to this diagnosis, she simply replied: "Thank you, my God." She was to be operated in Paris, but the disease grew so ravenous that the surgery had to take place in the US to undergo cobalt radiation to treat the malignant proliferation of which was then diagnosed as cancer. Her gynecologist said that it was due to a tumor. On Pentecost Monday, May 26, 1958, she suffered from a hemorrhage while working in her garden. ![]() Known as the 'Mother Margaret of Aleppo', in reference to the Venerable Mother Margaret Occhiena, she met them with kindness- sheltering, comforting, consoling, and feeding them. Soon, both the school and institute were met by refugees from the neighboring countries. The school finally opened its doors in 1948, amidst the then ravenous Israeli-Palestinian war. She once again turned to the Archbishop, in which he suggested they leave for Turin and request the then Rector Major of the Salesians, Pedro Ricaldone, to supply the school with teachers and spiritual guidance. But, less than a year in, they left Aleppo, subsequently abandoning the school, partly due to the conclusion of the promulgation of the ' French Mandate' which joined the states of Aleppo and Damascus to create the State of Syria. Matilde planned to set up the technical school as per advice Archbishop Fattal, which was to be run in part by the Marist Brothers. In accordance with Georges' will, she spearheaded the project and founding of the 'George Salem Foundation', in which she became its first acting president. ![]() It was after her husband's death that Matilde discovered that her true vocation was to "give herself to her neighbor with the greatest love" School and the Georges Salem Foundation īefore Georges' death, Matilde and her husband, advised by Bishop Isidoro Fattal, The Greco-Catholic Metropolitan of Aleppo, had thought of opening a technical school that would educate future Christian workers. Later on, Georges became ill with type 2 diabetes, which he would soon succumb to on October 26, 1944. They soon discovered that they would not have children of their own. Georges was a very austere, strict, possessive, and authoritarian man, in which Matilde would have to try very hard to calm down at times. At the age of 18, she was wed to one Georges Elias Salem, a successful young businessman, on August 15, 1922. She studied in a convent belonging to the Armenian Sisters of the Immaculate Conception, from which she developed intense internal prayer life. ![]() Matilde Salem, née Chelhot, was born in Aleppo, Syria on Novemto a wealthy family. 2 School and the Georges Salem Foundation.
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